Afdeling Molekulêre Biologie & Mensgenetika

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Immunomagnetic bead isolation of untouched cell populations for functional studies

Immunophenotyping of whole blood or cells for: Innate and adaptive cell frequencies and subsets, including maturation, trafficking, activation, proliferation and chemokine and cytokine expression

Laser Dissection Microscope & Fluorescence microscopy

Evaluation of cytokines and chemokines by ELISA and multiplexed bead array

Small Animal Research Facility: in vivoModelling

Experimental animals allow investigation into the immunological mechanisms in disease that would otherwise be impossible to perform in human studies. In this regard, the laboratory mouse serve as an ideal model to investigate immunological features of pre-clinical vaccine/drug tests and pathogenic infections, seeing as they display a similar cellular immune response as observed in humans. The infectious animal laboratory (Bio-safety level-2) is dedicated to creating and maintaining mice for research purposes in a completely germ-free environment, where mice are housed in sterile individual cages to provide researchers an environment which allow experimental infections with no competing background levels of pathogenic colonization. Ethical approval for the use of animals, vaccine/drug tests, performance of experimental infections and procedures are evaluated for approval by the Animal Ethics Committee of the 万博体育官网 of Stellenbosch (AEC). We aim to understand how host-pathogen interactions translate into clinical disease. The IRGL uniquely combines expertise in the field of pathogen biology and host immunity to utilize small animal models in order to:

Investigate molecular pathogenesis of infection biology
Uncover immunological pathways of communication between pathogen and host
Analyse host immune responses in diseases
Safety/immunogenicity of novel drug/vaccine candidates?